Serological surveillance in a sentinel network: pilot study report
PHE ePoster Library. Tripathy M. Apr 9, 2019; 257515; 15428
Ms. Manasa Tripathy
Ms. Manasa Tripathy
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Abstract Introduction
There have been calls for a world serology bank, as improved serological surveillance could provide data for vaccine development, diagnostic testing, and pandemic preparedness.We suggested that a rapid and cost-effective way of setting up a serology bank would be to use existing primary care sentinel networks such as the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC). RCGP RSC is one of the oldest sentinel networks with extensive clinical data, working for over 50 years with Public Health England (PHE) and its predecessor bodies. This study aims to demonstrate the feasibility of building a serology bank. MethodEight participating practices from RCGP RSC network collected blood samples from an age stratified sample of consenting adults. The patient's serology results, provided by PHE's Seroepidemiology Unit (SEU) were linked to their medical and vaccination history in the RCGP RSC database. We report the overall record matching and matched sample collection, percentage, number (n) and 95% confidence intervals (95%CI)..
In a span of 6 months, a total of 729 samples have been collected across all age bands. Out of these, 94% (92.2%-98.5%CI, n=685) were matched to a patient's record. The number of samples collected and the percentage matched for each age band are as follows: 18-29 (97%, 92.4%-100.0% CI, n=64), 30-39 (92.6%, 87.2%-98.5%CI, n=87), 40-49 (93.8%, 89.2%-98.5%% CI, n=122), 50-59 (93%, 88.5%-98.5%CI, n=146), 60-69 (92.4%, 87.9%-98.5%CI, n=122) and 70 and over (96%, 92.7%-100.0% CI, n=144). ConclusionThis pilot demonstrates the ability of the RCGP RSC to collect serology, with samples successfully matched with the patient's record. A full scale investigation, including children, has the potential to become a rich source of data for sero-epidemiology. Funding This work was funded by Higher Education Funding Council for England's (HEFCE) Industrial Strategy funding allocated to the University of Surrey.
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