Distinct susceptibility and invasiveness profiles in Salmonella Infantis from South Africa and the United Kingdom
PHE ePoster Library. Chattaway M. Apr 10, 2019; 257496; 15380
Dr. Marie Chattaway
Dr. Marie Chattaway
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Abstract
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Abstract Background:
Amongst Salmonella serovars, S. Infantis has become the fourth commonest cause of human salmonellosis in the EU (including the UK), causing 30% of Salmonella infections in Israel and is the commonest serovar in domestic fowl worldwide. In South Africa, little is known about the epidemiology of Infantis.
Methods:
Invasive index of was calculated as the number of all sequenced isolates from blood culture divided by isolates from stool referred to the UK reference laboratory and included historical isolates and all data since 2014. Sequence type was designated according to the standard Salmonella MLST scheme (mlsst.net). To investigate this we further sequenced S. Infantis isolates from Public Health England between 2004 and 2017 and from the National Institute for Communicable Disease between 2003 and 2016. Whole genome sequencing of isolates was performed on an Illumina NextSeq machine at the Quadram Insitute or on a HiSeq at PHE..
Results:
: Table 1: Invasiveness of selected serovars (2018 data only shown) Serovar / Invasiveness Index Paratyphi A /64.79Typhi /61.34Dublin /34.62Paratyphi B /26.74Typhimurium ST313 /16.22Infantis /1.49 Table 2: Invasiveness of S. Infantis sequence typeSequence type of S. Infantis / Invasiveness Index ST603 / 18.2ST32 / 2.2ST2283 / 1 Preliminary results from the sequencing of South African isolates suggests a higher burden of resistance in the UK (52.2% MDR) compared to South Africa (19.0%).
Conclusions:
S. Infantis as a serovar is not considered invasive. Of 2579 isolates received with metadata by PHE only 40 were invasive. Interestingly when ST603 and ST32 were analysed separately the invasiveness index (23/888, 2.5%) was much higher suggesting that sub-groups of the S. Infantis serovar may be highly invasive. Furthermore antimicrobial resistance appears to be driven by the presence of the pESI plasmid and we are currently exploring this further. Funding HPRU
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