Pneumococcal vaccine coverage in adults aged 18 to 64 years old, newly diagnosed with underlying medical conditions in the UK
PHE ePoster Library. Matthews I. 04/10/19; 257473; 15303
Ian Matthews
Ian Matthews
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Abstract Introduction
The UK recommends pneumococcal vaccination for individuals aged 2-64 years with certain underlying medical conditions. However, reports on vaccine coverage rate (VCR) for this population are very limited. The last data published (2009) only showed a VCR of 34.4%. This study aims to provide updated information on pneumococcal VCR in eligible adults aged 18-64 years, using Clinical Practice Research Datalink (CPRD) data.MethodThis retrospective cohort study was conducted using anonymised electronic health record (EHR) data from CPRD between 2011 and 2015. Individuals aged 18-64 years old within the specified clinical risk groups recommended for pneumococcal vaccination in the UK were included if they had continuous EHR data for 24 months before and >12 months after diagnosis of the underlying medical conditions. VCR by length of follow-up since diagnosis was analysed to understand factors associated with vaccination.
In total 99,154 adults aged 18-64 years within the clinical risk groups were identified. After 1 year, 13.6% of individuals had received pneumococcal vaccination, increasing to 32% after 4 years. Adults aged 50-64 years were more likely to be vaccinated than those aged 18-49 years. Immunosuppressed individuals were more likely to be vaccinated than any other clinical risk groups and immunosuppressed individuals with more than one underlying medical condition were the group most likely to be vaccinated. When considering time to vaccination, patients with cochlear implants had the shortest interval from initial diagnosis to vaccination, followed by immunosuppressed patients. The average time to vaccination among individuals with underlying medical conditions was 149 days.ConclusionVCR in 'At Risk' groups remains below the optimal level. A substantial number of adults with underlying medical conditions remain unvaccinated and not protected from pneumococcal disease. Further efforts to increase coverage is therefore desirable in the UK. Funding Funded by Merck & Co., Inc., Kenilworth, NJ, USA.
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