An Epigenome-wide methylation analysis of blood-lipid concentrations and statin-use in the Understanding Society: UK Household Longitudinal Study
PHE ePoster Library. Gorrie-Stone T. Apr 10, 2019; 257466; 15255
Tyler Gorrie-Stone
Tyler Gorrie-Stone
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Abstract
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Abstract Cardiovascular Disease (CVD) are the largest cause of death in human beings with numerous risk factors. One such risk factor is that of elevated blood lipid levels (HDL-C, LDL-C, Triglycerides and Total Cholesterol) that are a consequence of poor diet, a lack of exercise and genetics. Despite understanding how these risk factors contribute towards CVD we do not have a good mechanistic understanding how both CVD and atherosclerosis may manifest themselves in the human body - especially within the epigenome. Epigenome-wide association studies (EWAS) are a widely-used, non-candidate driven, approach to identifying relationships between epigenetic factors and environmental exposures. These EWAS have been successful at identifying epigenetic biomarkers which can be used diagnose or even predict health related outcomes.Here we performed an EWAS to explore the relationship of HDL-C concentration, Triglyceride concentration and statin-use with DNA methylation using the methylomes of 1,175 participants from the Understanding Society: UK Household Longitudinal Study, assayed on the newly released Illumina HumanMethylationEPIC BeadChip microarray platform. Within this study we reproduce the results of previous EWAS performed on a separate platform and identify 37 novel associations in a variety of lipid related genes. In addition we present the results of the first study to explore the effects of statin-use on the methylome. Funding Measurement of DNA methylation in Understanding Society: The UK Household Longitudinal Study was funded through an enhancement to Economic and Social Research Council (ESRC) grant ES/N00812X/1. M.S. and Y.B. were supported by the ESRC (grant ES/M008592/1). M.K. was supported by the University of Essex and ESRC (grant RES-596-28-0001). The time spent by E.H., J.M., and L.S. on this project was supported by Medical Research Council grant K013807.
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