Abstract IntroductionThe public health consequences of Mass Unemployment Events (MUEs) are comparable to other environmental and major emergency events, with extensive, long term, and intergenerational impact on health and wellbeing of workers, families and communities. The local and national response is usually focused on re-employment, with minimal consideration of wider health and social consequences. We present a multi-disciplinary public health response framework using an emergency planning model. Method: The framework was developed through rapid review of the literature, review of 12 international case studies and qualitative interviews with 23 international experts analysed thematically using ATLAS.ti . ResultsWe developed an eight step public health informed response framework to economic and employment shock. Response centers around individuals directly affected, addressing health and psychosocial needs, alongside re-employment and financial support. The framework includes addressing those same needs within the family and community, taking into consideration the potential for widening inequalities. Action is grounded in an understanding of geography and place, recognising that the success of a localised response will depend on the labour market, connectivity and infrastructure; but also the history, heritage and cultural identity. A need for a preventative approach to MUEs is highlighted, through planning and strategies for strengthening the resilience of communities. Conclusions An evidence based public health informed response framework has been developed to inform local and national action to address consequences of MUEs. A longer term preventative approach requires strengthening local assets, and resilience in individuals and communities to cope and recover from these events.